The Sugar Experiment: Primary and Secondary Outcomes

The individual experiments in the Lifestyle Experiment (Sugar, Fitness, Sleep and Food) will all have shorter term, more responsive metrics called primary outcomes. Those are outcomes that are likely to change over the short (usually 3 month) period of the individual experiment. We call these "responsive" metrics because we expect that they might respond in that short period whereas other metrics, although very important to the overall experiment, they take longer to respond. Some of these longer term metrics might change in this short period but they might not. Thus, these longer term metrics will be secondary outcomes for the individual experiments.

For the sugar experiment the primary outcomes are:

• Frequency of glucose spikes to more than 160 using CGM

• Average blood glucose using CGM

The secondary outcomes are:

• HbA1c

• Fasting Glucose

• Fasting Insulin Level

• Triglyceride Level

• Body Fat Percentage

• Waist Circumference

• LDL Cholesterol

• hsCRP